Egypt Sends Prime Minister to Gaza in Show of Solidarity

Wissam Nassar for The New York Times

The Gaza City funeral on Thursday of Ahmed al-Jabari, the Hamas military commander, killed in an Israeli attack. More Photos »

JERUSALEM — After a night of ferocious airstrikes in Gaza and rocket fire toward Israel, Egypt on Friday launched a remarkable diplomatic initiative, sending its prime minister to show support for Palestinians in the beleaguered enclave, a move that prompted his Israeli counterpart to agree to a temporary cease-fire even as Israeli commanders sent armored vehicles toward the overcrowded coastal strip and called up reservists for a possible invasion.

But the frail truce did not seem to be holding, or even taking root. While news reports said the Egyptian official had arrived in Gaza, Israel Radio said Palestinian militants fired 25 rockets into southern Israel, with one rocket striking a house. There were no immediate reports of casualties. The thump of what sounded like airstrikes was also audible in Gaza City, residents said, but the Israeli military no such strikes had taken place.

Prime Minister Benjamin Netanyahu had made the temporary cease-fire by Israel’s airplanes conditional on a corresponding halt to rocket fire from Gaza.

Residents in Gaza said the night was filled with the boom and crash of airstrikes, with loud explosions at dawn on Friday, a day after Israel and the Hamas rulers of Gaza brushed aside international calls for restraint and escalated their lethal conflict. In Gaza, Palestinian militants launched hundreds of rockets into Israeli territory, targeting Tel Aviv for the first time, and Israel intensified its aerial assaults.

Defense Minister Ehud Barak of Israel, expressing outrage over a pair of long-range Palestinian rockets that whizzed toward Tel Aviv and set off the first air-raid warning in the Israeli metropolis since it was threatened by Iraqi Scuds in the Persian Gulf war of 1991, said, “There will be a price for that escalation that the other side will have to pay.”

Within hours of the Tel Aviv air-raid warning, the Israeli Defense Forces said they had attacked 70 underground rocket-launching sites in Gaza and “direct hits were confirmed.” There were also unconfirmed reports that Israeli rockets had struck near Gaza’s Rafah crossing into Egypt, forcing the Egyptians to close it.

Early on Friday, the Israeli military said it had called up 16,000 army reservists, as preparations continued for a possible ground invasion for the second time in four years. Mr. Barak had authorized the call-up of 30,000 reservists, if needed, to move against what it considers an unacceptable security threat from smuggled rockets amassed by Hamas, the militant Islamist group that governs Gaza and does not recognize Israel’s right to exist.

It was not clear whether the show of Israeli force on the ground in fact portended an invasion or was meant as more of an intimidation tactic to further pressure Hamas leaders, who had all been forced into hiding on Wednesday after the Israelis killed the group’s military chief, Ahmed al-Jabari, in a pinpoint aerial bombing. But Mr. Netanyahu said he was ready to “take whatever action is necessary.”

At the same time, though, Israel signaled its concern to preserve its so-called cold peace with Egypt, with Mr. Netanyahu agreeing to the temporary cease-fire during the visit of Prime Minister Hesham Kandil of Egypt, who planned to visit the Al Shifa hospital and meet the Hamas cabinet. For the first time since Wednesday, Ismail Haniya, the Hamas prime minister, was seen in public on Friday accompanying Mr. Kandil, Israel Radio reported.

The visit of the Egyptian delegation is expected to last about three hours, and an official in Mr. Netanyahu’s office said by telephone that Israel had told Egypt that the cease-fire would hold as long as “there would not be hostile fire from the Gaza Strip into Israel.”

“Prime Minister Netanyahu is committed to the peace treaty with Egypt,” the official said. “That peace serves the strategic interests of both countries.” There was no suggestion that the Israelis were considering a more permanent cease-fire at this stage.

Overnight, Israel said it launched 150 airstrikes while Palestinian fired a dozen rockets into Israel — far fewer than the hundreds that have hurtled toward Israel in the past two days.

President Mohamed Morsi of Egypt ordered Mr. Kandil to Gaza both as an initiative to ease the crisis and in a display of solidarity that would have been improbable in the era of President Hosni Mubarak before his overthrow last year.

Isabel Kershner reported from Jerusalem, Rick Gladstone from New York, and Alan Cowell from Paris. Reporting was contributed by Fares Akram and Jodi Rudoren from Gaza, Rina Castelnuovo from Kiryat Malachi, Mayy El Sheikh and David D. Kirkpatrick from Cairo, Gabby Sobelman from Jerusalem, and Elisabeth Bumiller from Bangkok.

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Jesse & Joy take 4 Latin Grammys, Juanes wins too

LAS VEGAS (AP) — As Colombian rockero Juanes took home the best album award, Mexican brother-sister duo Jesse & Joy and their pop hit "Corre!" ran away with four awards at the 13th Annual Latin Grammys.

Hosted by actors Cristian De La Fuente and Lucero, Thursday night's event attracted stars from across the world and from dozens of Latin musical genres to the Mandalay Bay Events Center. Just like at a big family party, new faces shared the spotlight with older generations, and traditional styles mixed with electronica and Vegas dancers on stage.

Traditional Mexico met Las Vegas in a colorful number featuring Oaxaca native Lila Downs, Afro-Colombian singer Toto la Momposina and dancers in regional costumes, Carnival masques and skeleton makeup.

"What a great joy. Thank God, and all the fans," Juanes said as he dragged Dominican mereguero Juan Luis Guerra, who produced "MTV Unplugged," to the stage to accept the mini-gramaphone for best album at the close of the ceremony.

The winner for best new artist, the Mexican DJ trio 3ball MTY, threw down beats with America Sierra and Sky Blu of LMFAO. Pitbull performed "Don't Stop the Party" with dancers in gold spangled bikinis and hot pants. Juanes jammed with legendary guitarist Carlos Santana.

Michel Telo, the Brazilian sertanejo or country music singer, performed his hit, "Ai si eu te pego,"with Blue Man Group. Bachata heartthrob Prince Royce sang with veteran Mexican singer-songwriter Joan Sebastian. But the applause was also strong for the 1980s hit, "Yo No Te Pido la Luna," a duet between Spaniard Sergio Dalma and Mexican singer Daniela Romo, sporting a short silver hairdo following her bout with breast cancer.

Jesse & Joy also won for best contemporary pop vocal album for "Con Quien se Queda el Perro" and best short video for "Me voy."

"Thanks to people like Juanes and Juan Luis Guerro who have inspired us. Love and peace," Jesse said.

Guerra, who came into the ceremony as the leading nominee with six bids, won producer of the year for Juanes' album "MTV Unplugged."

Guerra performed "En el Cielo No Hay Hospital," which brought the audience to its feet to dance, and for a standing ovation.

Puerto Rican reggaeton singer Don Omar and Uruguayan alt rockers Cuarteto de Nos won two Latin Grammys each.

Downs won best folkloric album for "Pecados y Milagros." Colombian singer Fonseca won for best tropical fusion album, and Los Tucanes de Tijuana won best norteno album for "365 Dias," the narco-corrido band's 32nd album.

Milly Quezada brought home two statuettes, including best contemporary tropical album for "Aqui estoy yo."

"Long live merengue! Long live the Dominican Republic!" she said as she accepted the award. She also thanked Guerra, who helped produce the album.

Cuban-American jazz trumpeter Arturo Sandoval won three Latin Grammys, two for "Dear Diz (Every Day I Think of You)," but said these awards was just exciting as his first.

"The emotion is the same because one puts the same effort into each recording and the fact that the work is received well and respected by the public is very satisfying," he said.

The Latin Grammy celebration kicked off Wednesday with a tribute to Person of the Year winner, Caetano Veloso, one of the founders of the Tropicalismo movement.

The Brazilian singer, composer and activist sang in Spanish and Portuguese before Pitbull and Sensato closed with "Crazy People."

The event was broadcast live on Univision.

Interactive: http://hosted.ap.org/interactives/2012/latin-grammys/

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Recipes for Health: Baked Acorn Squash With Wild Rice — Recipes for Health

Andrew Scrivani for The New York Times

The filling here is a Greco-Italian fusion, with a little American (wild rice) thrown in. I’m usually not a fusion sort of cook, but I wanted something creamy like risotto to fill these squash. Look for small acorn squash so that each person can have one. They’ll be like miniature vegetarian (or vegan) turkeys.

6 small acorn squash

1 bunch kale or 1 10-ounce package stemmed and washed kale, stems picked out and discarded

1 cup cooked wild rice (1/3 cup uncooked)*

1 quart vegetable stock

2 tablespoons extra virgin olive oil

1/2 cup minced onion

Salt to taste

2/3 cup arborio rice

1 plump garlic clove, minced

1/2 cup dry white wine, like pinot grigio or sauvignon blanc

1/4 cup chopped fresh dill

1/4 cup chopped flat-leaf parsley Freshly ground pepper to taste

1/4 to 1/2 cup freshly grated Parmesan cheese (1 to 2 ounces) (optional)

Cayenne or freshly grated nutmeg to taste (optional)

1. Heat the oven to 425 degrees. Line a baking sheet with foil and brush the foil with olive oil. Place the squash in the oven and bake 30 minutes. Each squash should be intact but beginning to give on the side it’s resting on, and soft enough to cut through. Remove from the oven and let sit for 15 minutes, until the squash has cooled slightly. Then, resting a squash on the slightly flattened side that it was sitting on in the oven, cut away the top third. You will be putting the top “cap” back on once the squash is filled, so cut it off in one neat slice. Scrape out the seeds and membranes from both pieces and set aside. Repeat for the remaining squash. Turn the oven heat down to 350 degrees. Oil a baking dish or sheet pan that can accommodate all of the squash.

2. Meanwhile, blanch the kale in a large pot of salted boiling water for 2 to 4 minutes, until just tender. Transfer to a bowl of cold water, drain and squeeze out excess water. Chop medium-fine and set aside. Cook the wild rice, following the directions below, and set aside.

3. Put the stock into a saucepan and bring it to a simmer over low heat, with a ladle nearby. Heat 1 tablespoon of the olive oil over medium heat in a wide, heavy nonstick saucepan or skillet. Add the onion and a generous pinch of salt, and cook gently until it is just tender, 3 to 5 minutes.

4. Add the arborio rice and garlic and stir until the grains separate and begin to crackle. Add the wine and stir until it has been absorbed. Begin adding the simmering stock, a couple of ladlefuls (about 1/2 cup) at a time. The stock should just cover the rice, and should be bubbling, not too slowly but not too quickly. Cook, stirring often, until it is just about absorbed. Add another ladleful or two of the stock and continue to cook in this fashion, adding more stock and stirring when the rice is almost dry. You do not have to stir constantly, but stir often. Continue to add stock and stir until the rice is almost tender, about 20 minutes. The rice should still be a little chewy. Add another ladleful of stock and stir in the kale, wild rice and herbs. Stir together until the stock is just about absorbed, about 5 minutes, and add another ladleful of stock. Remove from the heat. Add pepper, taste and adjust seasonings. Stir in the remaining olive oil and the Parmesan if using.

5. Season the surface of the acorn squash with salt, pepper and nutmeg or cayenne (if desired). Fill the hollowed-out squash with the risotto. Place the tops back on the squash and put them in the baking dish or on the sheet pan.

6. Bake 40 minutes, or until the squash is tender all the way through when pierced with a knife.

* To cook the wild rice, bring 2 cups of the stock or water to boil in a medium saucepan. Add salt to taste and the wild rice. When the water returns to the boil, reduce the heat, cover and simmer 40 to 45 minutes, until the rice is tender and has begun to splay. Drain and transfer the rice to a large bowl.

Yield: 6 to 8 generous servings

Advance preparation: The risotto can be made a day ahead, but you will want to heat it and add a little more stock to get the creaminess that will be lost overnight.

Nutritional information per serving (6 servings): 366 calories; 5 grams fat; 1 gram saturated fat; 1 gram polyunsaturated fat; 3 grams monounsaturated fat; 0 milligrams cholesterol; 75 grams carbohydrates; 9 grams dietary fiber; 53 milligrams sodium (does not include salt to taste); 9 grams protein

Nutritional information per serving (8 servings): 274 calories; 4 grams fat; 1 gram saturated fat; 1 gram polyunsaturated fat; 3 grams monounsaturated fat; 0 milligrams cholesterol; 56 grams carbohydrates; 7 grams dietary fiber; 40 milligrams sodium (does not include salt to taste); 6 grams protein

Martha Rose Shulman is the author of “The Very Best of Recipes for Health

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In BP Indictments, U.S. Shifts to Hold Individuals Accountable

HOUSTON — Donald J. Vidrine and Robert Kaluza were the two BP supervisors on board the Deepwater Horizon rig who made the last critical decisions before it exploded. David Rainey was a celebrated BP deepwater explorer who testified to members of Congress about how many barrels of oil were spewing daily in the offshore disaster.

Mr. Vidrine, 65, of Lafayette, La., and Mr. Kaluza, 62, of Henderson, Nev., were indicted on Thursday on manslaughter charges in the deaths of 11 fellow workers; Mr. Rainey, 58, of Houston, was accused of making false estimates and charged with obstruction of Congress. They are the faces of a renewed effort by the Justice Department to hold executives accountable for their actions. While their lawyers said the men were scapegoats, Attorney General Eric H. Holder Jr. said at a news conference, “I hope that this sends a clear message to those who would engage in this kind of reckless and wanton conduct.”

The defense lawyers were adamant that their clients would contest the charges, and prosecutors said that the federal investigations were continuing.

Legal scholars said that by charging individuals, the government was signaling a return to the practice of prosecuting officers and managers, and not just their companies, in industrial accidents, which was more common in the 1980s and 1990s.

“If senior managers cut corners, or if they make decisions that put people in harm’s way, then the criminal law is appropriate,” said Jane Barrett, a University of Maryland law professor and former federal prosecutor.

She noted that it was unusual for the Justice Department to prosecute individual corporate officers in recent years, including in the 2005 BP Texas City refinery explosion that killed 15 workers, where only the company was fined.

BP said on Thursday it would pay $4.5 billion in fines and other payments, and the corporation pleaded guilty to 14 criminal charges in connection with spill. The $1.26 billion in criminal fines was the highest since Pfizer in 2009 paid $1.3 billion for illegally marketing an arthritis medication.

The crew was drilling 5,000 feet under the sea floor 41 miles off the Louisiana coast in April 2010 when they lost control of the well during its completion. They tested the pressure of the well, but misinterpreted the test results and underestimated the pressure exerted by the flow of oil or gas up the well. Had the results been properly interpreted, operations would have ceased.

Mr. Vidrine and Mr. Kaluza were negligent in their reading of the kicks of gas popping up from the well that should have suggested that the Deepwater Horizon crew was fast losing control of the ill-fated Macondo well, according to their indictment, and they failed to act or even communicate with their superiors. “Despite these ongoing, glaring indications on the drill pipe that the well was not secure, defendants Kaluza and Vidrine again failed to phone engineers onshore to alert them to the problem, and failed to investigate any further,” the indictment said.

The indictment said they neglected to account for abnormal pressure test results on the well that indicated problems, accepting “illogical” explanations from members of the crew, which caused the “blowout of the well to later occur.”

In a statement, Mr. Kaluza’s lawyers said: “No one should take any satisfaction in this indictment of an innocent man. This is not justice.”

Bob Habans, a lawyer for Mr. Vidrine, called the charges “a miscarriage of justice.”

“We cannot begin to explain or understand the misguided effort of the United States attorney and the Department of Justice to blame Don Vidrine and Bob Kaluza, the other well site leader, for this terrible tragedy.”

Several government and independent reports over the last two years have pointed to sloppy cement jobs in completing the well or the poor design of the well itself as major reasons for the spill. But none of the three was indicted in connection with those problems.

Mr. Rainey was a far more senior executive, one who was known around Houston and the oil world as perhaps the most knowledgeable authority on Gulf oil and gas deposits. According to his indictment, Mr. Rainey obstructed Congressional inquiries and made false statements by underestimating the flow rate to 5,000 barrels a day even as millions were gushing into the Gulf.

Campbell Robertson contributed reporting.

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Frederick Humphries, F.B.I. Agent in Petraeus Case

DOVER, Fla. — The F.B.I. agent who spurred the investigation that led to the resignation of David H. Petraeus as C.I.A. director is a “hard-charging” veteran who helped investigate the foiled millennium terrorist plot in 1999, colleagues said on Wednesday.

Steve Ringman/The Seattle Times

Frederick W. Humphries II at the F.B.I. office in Seattle in 1999.

Timeline: Petraeus Affair

Pool photo by Paul Richards

Frederick W. Humphries II helped start the inquiry that led to the resignation of David H. Petraeus, center, as C.I.A. director and ensnared the commander of NATO forces in Afghanistan, Gen. John R. Allen, left, shown with Leon E. Panetta in 2011.

The agent, Frederick W. Humphries II, 47, is also described by former colleagues as relentless in his pursuit of what he sees as wrongdoing, which appears to describe his role in the F.B.I. investigation involving Mr. Petraeus. Suspecting that the case involved serious security issues and was being stalled, possibly for political reasons — a suspicion his superiors say was unjustified — he took his concerns to Congressional Republicans.

“Fred is a passionate kind of guy,” one former colleague said. “He’s kind of an obsessive type. If he locked his teeth onto something, he’d be a bulldog.”

The question of how and why the F.B.I. opened the investigation that has had such momentous consequences has been central from the moment Mr. Petraeus stepped down Friday. The emerging portrait of the agent who initiated the inquiry is another step toward an answer.

Mr. Humphries, who was identified on Wednesday by law enforcement colleagues, took the initial complaint from Jill Kelley, a Tampa woman active in local military circles and a personal friend, about anonymous e-mails that accused her of inappropriately flirtatious behavior toward Mr. Petraeus.

The subsequent cyberstalking investigation uncovered an extramarital affair between Mr. Petraeus and Paula Broadwell, his biographer, who agents determined had sent the anonymous e-mails. It also ensnared Gen. John R. Allen, the commander of NATO forces in Afghanistan, after F.B.I. agents discovered what a law enforcement official said on Wednesday were sexually explicit e-mail exchanges between him and Ms. Kelley.

A spokesman for Ms. Kelley provided her version of events in two conference calls with reporters on Wednesday. Ms. Kelley’s concern when she took the e-mails to Mr. Humphries was that she feared the sender was “stalking” Mr. Petraeus and General Allen, said the spokesman, who asked not to be identified.

“She asks the agent, ‘What do you make of this?’ ” the spokesman said. “The agent said: ‘This is serious. They seem to know the comings and goings of a couple of generals.’ ”

General Allen himself had received a similar anonymous e-mail message, sent by someone identified as “kelleypatrol,” advising him to stay away from Ms. Kelley. The general forwarded it to Ms. Kelley, and they discussed a concern that someone was cyberstalking them.

On Tuesday, Defense Secretary Leon E. Panetta said he had asked the Senate to postpone a confirmation hearing for General Allen’s next assignment while the department’s inspector general reviewed his e-mail correspondence with Ms. Kelley, which was discovered by F.B.I. agents investigating her initial complaint.

Pentagon officials said the review covered more than 10,000 pages of documents that included “inappropriate” messages. But associates of General Allen have said that the two exchanged about a dozen e-mails a week since meeting two years ago and that his messages were affectionate but platonic.

A law enforcement official, speaking on the condition of anonymity, disputed that assertion on Wednesday, saying some messages were clearly sexual. Investigators were confident “the nature of the content warranted passing them on” to the inspector general, the official said.

In a statement on Wednesday, General Allen’s military counsel said he intended to cooperate fully with the inspector general’s investigation. “To the extent there are questions about certain communications by General Allen, he shares in the desire to resolve those questions as completely and quickly as possible,” said the statement from Col. John G. Baker, the chief defense counsel of the Marine Corps.

Michael S. Schmidt reported from Dover, Scott Shane from Washington and Alain Delaquérière from New York. Eric Schmitt, Thom Shanker, Charlie Savage and Sheryl Gay Stolberg contributed reporting from Washington.

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Erdrich wins her first National Book Award

NEW YORK (AP) — The National Book Awards honored both longtime writers and new authors, from Louise Erdrich for "The Round House" to Katherine Boo for her debut work, "Beyond the Beautiful Forevers."

Erdrich, 58, has been a published and highly regarded author for nearly 30 years but had never won a National Book Award until being cited Wednesday for her story, the second of a planned trilogy, about an Ojibwe boy and his quest to avenge his mother's rape. A clearly delighted and surprised Erdrich, who's part Ojibwe, spoke in her tribal tongue and then switched to English as she dedicated her fiction award to "the grace and endurance of native people."

The works of two other winners also centered on young boys — Boo's for nonfiction, and William Alexander's fantasy "Goblin Secrets," for young people's literature. David Ferry won for poetry.

Boo's book, set in a Mumbai slum, is the story of a boy and his harsh and illuminating education in the consequences of crime or perceived crime. The author, a Pulitzer Prize-winning journalist currently on staff with The New Yorker, said she was grateful for the chance to live in a world she "didn't know" and for the chance to tell the stories of those otherwise ignored. She praised a fellow nominee and fellow Pulitzer-winning reporter, the late Anthony Shadid, for also believing in stories of those without fame or power.

Boo was chosen from one of the strongest lists of nonfiction books in memory, from the fourth volume of Robert Caro's Lyndon Johnson series to Shadid's memoir "House of Stone." Finalists in fiction, which in recent years favored lesser known writers, included such established names as Dave Eggers and Junot Diaz. Publishers have been concerned that the National Book Awards have become too insular and are considering changes, including expanding the pool of judges beyond writers.

Winners, chosen by panels of their peers, each will receive $10,000.Judges looked through nearly 1,300 books.

Ferry is a year older than one of the night's honorary recipients, Elmore Leonard. Ferry, 88, won for "Bewilderment: New Poems and Translations," a showcase for his versatile style. He fought back tears as he confided that he thought there was a chance for winning because he "was so much older" than the other nominees. Attempting to find poetry in victory, he called the award a "pre-posthumous" honor.

Alexander quoted fellow fantasy writer Ursula K. Le Guin in highlighting the importance of stories for shaping kids' imaginations and making the world a larger place than the one they live in.

"We have to remember that," Alexander said.

The ceremony was hosted by commentator-performer Faith Salie and went smoothly even though Superstorm Sandy badly damaged the offices of the award's organizer, the National Book Foundation, whose staffers had to work with limited telephone and mail access.

Honorary prizes were given to Leonard and New York Times publisher and chairman Arthur O. Sulzberger Jr.

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Alzheimer’s Tied to Mutation Harming Immune Response

Alzheimer’s researchers and drug companies have for years concentrated on one hallmark of Alzheimer’s disease: the production of toxic shards of a protein that accumulate in plaques on the brain.

But now, in a surprising coincidence, two groups of researchers working from entirely different starting points have converged on a mutated gene involved in another aspect of Alzheimer’s disease: the immune system’s role in protecting against the disease. The mutation is suspected of interfering with the brain’s ability to prevent the buildup of plaque.

The discovery, researchers say, provides clues to how and why the disease progresses. The gene, known as TREM2, is only the second found to increase Alzheimer’s risk substantially in older people.

“It points very specifically to a potential metabolic pathway that you could intervene in to change the course of Alzheimer’s disease,” said William Thies, chief medical and scientific officer of the Alzheimer’s Association.

Much work remains to be done before scientists understand precisely how the newly discovered gene mutation leads to Alzheimer’s, but already there are some indications from studies in mice. When the gene is not mutated, white blood cells in the brain spring into action, gobbling up and eliminating the plaque-forming toxic protein, beta amyloid. As a result, Alzheimer’s can be staved off or averted.

But when the gene is mutated, the brain’s white blood cells are hobbled, making them less effective in their attack on beta amyloid.

People with the mutated gene have a threefold to fivefold increase in the likelihood of developing Alzheimer’s disease in old age.

The intact gene, says John Hardy of University College London, “is a safety net.” And those with the mutation, he adds, “are living life without a safety net.” Dr. Hardy is lead author of one of the papers.

The discovery also suggests that a new type of drug could be developed to enhance the gene’s activity, perhaps allowing the brain’s white blood cells to do their work.

“The field is in desperate need of new therapeutic agents,” said Alison Goate, an Alzheimer’s researcher at Washington University in St. Louis who contributed data to Dr. Hardy’s study. “This will give us an alternative approach.”

The fact that two research groups converged on the same gene gives experts confidence in the findings. Both studies were published online Wednesday in The New England Journal of Medicine. “Together they make a good case that this really is an Alzheimer’s gene,” said Gerard Schellenberg, an Alzheimer’s researcher at the University of Pennsylvania who was not involved with the work.

The other gene found to raise the odds that a person will get Alzheimer’s, ApoE4, is much more common and confers about the same risk as the mutated version of TREM2. But it is still not clear why ApoE4, discovered in 1993, makes Alzheimer’s more likely.

Because the mutations in the newly discovered gene are rare, occurring in no more than 2 percent of Alzheimer’s patients, it makes no sense to start screening people for them, Dr. Thies said. Instead, the discovery provides new clues to the workings of Alzheimer’s disease.

To find the gene, a research group led by Dr. Kari Stefansson of deCODE Genetics of Iceland started with a simple question.

“We asked, ‘Can we find anything in the genome that separates those who are admitted to nursing homes before the age of 75 and those who are still living at home at 85?’ ” he said.

Scientists searched the genomes of 2,261 Icelanders and zeroed in on TREM2. Mutations in that gene were more common among people with Alzheimer’s, as well as those who did not have an Alzheimer’s diagnosis but who had memory problems and might be on their way to developing Alzheimer’s.

The researchers confirmed their results by looking for the gene in people with and without Alzheimer’s in populations studied at Emory University, as well as in Norway, the Netherlands and Germany.

The TREM2 connection surprised Dr. Stefansson. Although researchers have long noticed that the brain is inflamed in Alzheimer’s patients, he had dismissed inflammation as a major factor in the disease.

“I was of the opinion that the immune system would play a fairly small role, if any, in Alzheimer’s disease,” Dr. Stefansson said. “This discovery cured me of that bias.”

Meanwhile, Dr. Hardy and Rita Guerreiro at University College London, along with Andrew Singleton at the National Institute on Aging, were intrigued by a strange, rare disease. Only a few patients had been identified, but their symptoms were striking. They had crumbling bones and an unusual dementia, sclerosing leukoencephalopathy.

“It’s a weird disease,” Dr. Hardy said.

He saw one patient in her 30s whose brain disease manifested in sexually inappropriate behavior. Also, her bones kept breaking. The disease was caused by mutations that disabled both the copy of TREM2 that she had inherited from her mother and the one from her father.

Eventually the researchers searched for people who had a mutation in just one copy of TREM2. To their surprise, it turned out that these people were likely to have Alzheimer’s disease.

They then asked researchers around the world who had genetic data from people with and without Alzheimer’s to look for TREM2 mutations.

“Sure enough, they had good evidence,” Dr. Hardy said. The mutations occurred in one-half of 1 percent of the general population but in 1 to 2 percent of patients with Alzheimer’s disease.

“That is a big effect,” Dr. Hardy said.

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Obama Meets C.E.O.’s as Fiscal Reckoning Nears

Luke Sharrett for The New York Times

Ursula M. Burns, chief of Xerox, said the president discussed few specifics of a potential agreement but emphasized that “we cannot go over the fiscal cliff.”

WASHINGTON — President Obama extended an olive branch to business leaders Wednesday, seeking their support as he prepared to negotiate with Congressional Republicans over the fiscal impasse in Washington.

If Congress and the president cannot reach a deal to reduce the deficit by January, more than $600 billion in tax increases and spending cuts will go into effect immediately — a prospect many chief executives and others warn could tip the economy back into recession.

Even so, Mr. Obama has some fence-mending to do before he can count on any serious backing from the business community.

“The president brought up that he hadn’t always had the best relationship with business, and he didn’t think he deserved that, but he understood that’s where things were and wanted it to be better,” said David M. Cote, chief executive of Honeywell. He was one of a dozen corporate leaders invited to meet Mr. Obama at the White House for 90 minutes Wednesday afternoon, after the president’s first news conference since the election.

While Mr. Obama did not present a detailed plan at Wednesday’s meeting or reveal what he would propose in terms of new corporate taxes, he strongly reiterated that he would not allow tax cuts for the middle class to expire. The president, according to attendees and aides, said he was committed to a balanced approach of reductions in entitlements and other government spending and increases in revenue.

With time running out, many people expect the president and Republican leaders in Congress to come up with a short-term compromise that prevents the full slate of tax increases and spending cuts from hitting in January. That would give both sides more time to come up with a far-reaching deal on entitlement spending, even as they work on a broad tax overhaul later next year.

One corporate official briefed on the meeting said that the chief executives came away with a sense that Mr. Obama was poised to present a more formal proposal in the next few days, but that he did not press them for support on particular policies. “It was more of a back and forth,” he said.

The chief executives from some of the country’s biggest and best-known companies, including Procter & Gamble and I.B.M., were not unified on everything, according to one who was interviewed after the meeting.

Many of the executives who described the meeting would speak only on condition of anonymity.

The outreach to business comes as both the White House and corporate America maneuver ahead of the year-end deadline, as well as the beginning of Mr. Obama’s second term. Many executives were put off by what they saw as antibusiness rhetoric coming from the White House in his first term, and many also oppose tax increases on the rich that Mr. Obama favors but would hit them personally.

Both sides have plenty to gain from a better relationship. Business leaders want to buffer their image after the recession and the financial crisis, while Mr. Obama would gain valuable leverage if he could persuade even a few chief executives to come out in favor of higher taxes on people with incomes over $250,000.

Lloyd C. Blankfein, chief executive of Goldman Sachs, publicly endorsed higher tax rates in an opinion article published in The Wall Street Journal on Wednesday.

“I believe that tax increases, especially for the wealthiest, are appropriate, but only if they are joined by serious cuts in discretionary spending and entitlements,” he wrote.

While Mr. Blankfein and other Wall Street leaders have been speaking out about the dangers of the fiscal impasse, only one executive from the financial services industry, Kenneth I. Chenault of American Express, was at Wednesday’s meeting.

Afterward, the corporate leaders seemed pleased with the tone of the meeting but cautious about the prospect of finding common ground with the White House on the budget choices facing Congress and the president.

“I’d say everybody came away feeling pretty good about the whole discussion,” Mr. Cote said. “Now, all of us are C.E.O.’s, so we’ve learned not to confuse words with results. And that’s what we still need to see.”

Ursula M. Burns, chief executive of Xerox, who was also at the meeting, said afterward that it was clear that “we’re going to have to work through some sticking points.” But while “we didn’t get into too many specifics,” she said, it was also made clear that “we cannot go over the fiscal cliff.”

Ms. Burns’s comments about the potentially dire consequences of the fiscal impasse echoed those of other chief executives, including many in the Business Roundtable, which began an ad campaign Tuesday calling on lawmakers to resolve the issue quickly. The Campaign to Fix the Debt, a new group with a $40 million budget and the support of many Fortune 500 chiefs, began its own ad campaign on Monday.

Michael T. Duke, chief executive of Wal-Mart Stores, warned in a statement after the meeting that “before the end of the year, Washington needs to find an agreement to avoid the fiscal cliff.” He said Walmart customers “are working hard to adapt to the ‘new normal,’ but their confidence is still very fragile. They are shopping for Christmas now, and they don’t need uncertainty over a tax increase.”

 

Helene Cooper reported from Washington and Nelson D. Schwartz from New York. Jackie Calmes contributed reporting from Washington.

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Tampa Social Scene at Center of Petraeus Scandal

TAMPA, Fla. — Jill and Scott Kelley moved here about a decade ago, taking up residence in a huge redbrick home with a spectacular view of the water on Bayshore Boulevard, the city’s most fashionable street. They quickly established themselves as social hosts to the powerful four-star officers who run two of the nation’s most important military commands.

Chris O'Meara/Associated Press

Ms. Kelley, of Tampa, Fla., filed a complaint that led to the Petraeus inquiry.

The Kelleys were known for their lavish parties, with extravagant buffets, flowing Champagne, valet parking and cigars for guests from nearby MacDill Air Force Base, including David H. Petraeus and Gen. John R. Allen, who now commands troops in Afghanistan. “Tampa is the kind of community where, if you’re new to the community, you can carve out your own niche,” said Pam Iorio, the city’s former mayor, who recalls mingling with Mr. Petraeus and his wife, Holly, at the Kelleys’ home. “They decided to carve out a niche with the military.”

Now the social link between Tampa’s military and civilian elite is at the center of an unfolding Washington scandal that has already cost Mr. Petraeus his job as director of the Central Intelligence Agency and has ensnared General Allen, who was Mr. Petraeus’s deputy when he was here from 2008 to 2010.

At the heart of the investigation is the Tampa woman who prompted it: Ms. Kelley, 37, who received threatening anonymous e-mails that set off an F.B.I. investigation revealing that Mr. Petraeus had an affair with his biographer, Paula Broadwell. On Tuesday, General Allen was caught up in the scandal, when the Pentagon said that it was investigating whether he had engaged in “inappropriate communication” with Ms. Kelley; associates of the general say the messages were innocent, and President Obama voiced support for him.

Records show that Ms. Kelley and her husband, a doctor, have been subject to a string of lawsuits over debts, according to a report in The Tampa Bay Times, which said the Kelleys owed a bank nearly $2.2 million, including attorney fees, on a building they own. They also ran a cancer charity, which appears to be defunct. A 2007 tax filing, the latest available, shows the charity raised $157,284 that year, but spent just $58,417 on program services, described as conducting research to improve the lives of terminally ill adult cancer patients.

Their parties, though, were the talk of the town. In February 2010, a gossip column in The Tampa Bay Times reported that Mr. Petraeus and his wife arrived escorted by 28 police officers on motorcycles to a pirate-themed party at the Kelleys’ home, to mark Tampa’s Gasparilla Pirate Fest, an annual event. Guests dined on lamb chops and crab cakes, beside hot dog and funnel cake carts, the paper said.

The couple appeared to be well regarded at MacDill, home to Central Command, which runs the wars in Iraq and Afghanistan and hosts officers from more than 50 foreign countries, and Special Operations Command, which trains commandos for missions like the one that killed Osama bin Laden. The two sit side by side on the base, where generals, admirals and other high-ranking officers live in elegant homes on a spit of land that juts into Tampa Bay. Often, they invite community leaders to social receptions of their own.

Indeed, Mr. Petraeus and his wife grew so close to the Kelleys that they hosted the couple and Ms. Kelley’s twin sister, Natalie Khawam, for Christmas dinner last year. Both General Allen and Mr. Petraeus also wrote letters to a District of Columbia court vouching for Ms. Khawam in a child custody dispute.

That kind of closeness — and the Kelleys’ fancy parties — strike some military people as odd.

“I have never known there to be groupies around generals,” said Jacey Eckhart, the military spouse editor of the Web site military.com. “But just like in every other field of endeavor, there is a certain excitement around people that have great power. And generals, like captains of industry and certain kinds of celebrities, wield a certain kind of power.”

MacDill Air Force Base is a driving force behind the Tampa economy. The local Chamber of Commerce estimates $6.7 billion a year flows into the Tampa Bay area from the base. Military contractors and other defense-related companies dot the city. Business deals are often made in the plentiful strip clubs and steakhouses.

Michael S. Schmidt reported from Tampa, Fla., and Sheryl Gay Stolberg from Washington. Michael Wines contributed reporting from New York, and Matthew Rosenberg and Ron Nixon from Washington.

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Papa John’s falls on news of class-action suit

NEW YORK (AP) — Shares of Papa John‘s declined on Tuesday following news of class-action certification for a lawsuit that claims the pizza chain had unsolicited text messages sent to cell phones.

THE SPARK: The lawsuit filed with the U.S. District Court for the Western District of Washington in Seattle claims Papa John‘s violated state and federal law when they had the marketing company OnTime4U send unsolicited text messages on its behalf to cell phones advertising their pizza products. The lawsuit says that 500,000 illegal text messages were sent to Papa John’s customers across the U.S.

Papa John’s faces potential damages of more than $ 250 million. The plaintiffs may each potentially receive $ 500 or more in damages for each text message.

Messages left with Papa John’s seeking comment were not immediately returned.

SHARE ACTION: Papa John’s International Inc.’s stock fell 34 cents to $ 49.10 in afternoon trading after dropping as low as $ 46.72 earlier in the session. Over the past year, the shares have traded in a range of $ 35.21 to $ 56.41.

Gadgets News Headlines – Yahoo! News

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Guilty plea expected by reputed Conn. mobster

HARTFORD, Conn. (AP) — A 76-year-old reputed Connecticut mobster is expected to plead guilty in a weapons and prescription drugs case that has revealed the FBI's belief that he has information about the largest art heist in history.

Robert Gentile, of Manchester, has a change-of-plea hearing scheduled in Hartford federal court on Wednesday. He has pleaded not guilty to allegations he illegally possessed firearms and explosives and sold illegally obtained prescription drugs.

It's not clear whether there is a plea deal. Gentile's lawyer and a spokesman for the U.S. attorney's office declined to comment about the hearing.

Gentile hasn't been charged in the museum theft. His attorney, A. Ryan McGuigan, has said his client knows nothing about the heist and isn't a Mafia member.

At a court hearing in March, Assistant U.S. Attorney John Durham said the FBI believes Gentile "had some involvement in connection with stolen property" related to a 1990 heist at Boston's Isabella Stewart Gardner Museum.

Thieves disguised as police officers struck as the city finished celebrating St. Patrick's Day, tying up two guards and making off with 13 pieces of art including masterworks by Rembrandt, Vermeer, Degas and Manet worth more than a half-billion dollars. The artwork hasn't been found and the museum is still offering a $5 million reward.

Durham has said that FBI agents had unproductive discussions with Gentile about the theft, but he didn't elaborate on his allegations. Durham also said the FBI believes Gentile is a made member of a Philadelphia crime family.

Gentile has been detained since February when he and an associate, Anthony Parente, were charged with selling illegally obtained prescription drugs including OxyContin, Dilaudid and Percocet.

Authorities searched Gentile's home and reported finding homemade dynamite sticks, several guns, ammunition, homemade silencers, a bulletproof vest, handcuffs, police scanners, brass knuckles and $22,000 in cash at the bottom of a grandfather clock.

Federal agents swarmed Gentile's home again in May in what McGuigan called a veiled attempt to find the stolen paintings. McGuigan said at the time that the FBI got a new warrant allowing the use of ground-penetrating radar to look for buried weapons, but he believed they really were looking for the artwork.

"This is nonsense," McGuigan said in May. "This is the FBI. Are you trying to tell me they missed something the first time? They're trying to find $500 million of stolen artwork. ... All they're going to find is night crawlers."

All McGuigan would say on Tuesday was that Gentile has been confined in a cell by himself and "looks terrible."

"They have him in a hole 24 hours a day where he can't see anybody," McGuigan said.

Gentile is charged with three weapons crimes that each carry up to 10 years in prison and six drug crimes that carry up to 20 years in prison apiece. He wasn't supposed to have any guns because of a 1990s larceny conviction.

The drug case against Parente remains pending. He is free on bail.

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Recipes for Health: Roasted Eggplant and Chickpeas — Recipes for Health

Andrew Scrivani for The New York Times

Eggplant is always a good, substantial vegetable to use for a vegetarian main dish. The chickpeas and the feta provide plenty of protein. Vegans can leave out the feta and substitute sugar or agave nectar for the honey.

 

1/4 cup extra virgin olive oil

2 garlic cloves, minced

1 28-ounce can chopped tomatoes, with juice, pulsed to a coarse purée

1 teaspoon mild honey (more to taste)

1/4 to 1/2 teaspoon cinnamon, to taste

Salt to taste

1 large or 2 medium eggplants (about 1 1/4 pounds), cut into 1/3-inch-thick slices

3 cups cooked chickpeas (2 cans, drained and rinsed, or, 1 1/2 cups dried – about 3/4 pound

4 ounces feta, crumbled (3/4 cup)

1 teaspoon dried oregano, preferably Greek or Turkish

 

1. Make the tomato sauce. Heat 1 tablespoon of the olive oil in a heavy skillet or wide saucepan over medium heat, and add the garlic. Cook, stirring, until it smells fragrant, about 30 seconds, and add the tomatoes, honey, salt to taste and cinnamon. Cook over medium heat until the tomatoes have cooked down and the sauce is fragrant, about 20 minutes. Taste and adjust seasonings.

2. Meanwhile, heat the oven to 425 degrees. Line a baking sheet with aluminum foil and brush the boil with olive oil. Place the eggplant slices on the baking sheet, salt lightly and brush with olive oil. Place in the oven and bake 20 minutes, or until eggplant is lightly browned and soft all the way through. Remove from the heat. Fold the aluminum foil over and crimp the edges together so that the eggplant steams as it cools. Do this in batches if you need more than one baking sheet. Turn the oven down to 350 degrees.

3. Oil a 2-quart baking dish or gratin. Place the chickpeas in the baking dish and stir in 1 cup of the tomato sauce. Layer the eggplant over the chickpeas and top with the remaining tomato sauce. Sprinkle the feta over the top and drizzle on any remaining olive oil. Sprinkle with the oregano and cover tightly with foil. Bake 30 minutes. Uncover and bake another 10 minutes, until the dish is bubbling.

Yield: 6 servings

Advance preparation: The eggplant slices can be cooked up to a day ahead. Hold in the refrigerator, covered. The tomato sauce will keep for 3 days in the refrigerator and freezes well.

Nutritional information per serving: 366 calories; 16 grams fat; 4 grams saturated fat; 2 grams polyunsaturated fat; 8 grams monounsaturated fat; 17 milligrams cholesterol; 44 grams carbohydrates; 14 grams dietary fiber; 431 milligrams sodium (does not include salt to taste); 15 grams protein

Martha Rose Shulman is the author of “The Very Best of Recipes for Health

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At Microsoft, Sinofsky Seen as Smart but Abrasive

On a warm night in late October, Steven Sinofsky stood on a platform in New York’s Times Square, smiling as a huge crowd roared at the unveiling of a Microsoft retail store, where Windows 8 and the company’s new Surface tablet were about to go on sale.

Less than three weeks later, Mr. Sinofsky — who, as the head of Windows, was arguably the second-most important leader at Microsoft — suddenly left the company. His abrasive style was a source of discord within Microsoft, and he and Steven A. Ballmer, Microsoft’s chief executive, agreed that it was time for him to leave, according to a person briefed on the situation who was not authorized to speak publicly about it.

Mr. Sinofsky was widely admired for his effectiveness in running one of the biggest and most important software development organizations on the planet. But his departure, which Microsoft announced late on Monday, parallels in many respects that of Scott Forstall, the headstrong former head of Apple’s mobile software development, who was fired by Apple’s chief executive, Timothy D. Cook, in late October.

Both cases underscore a quandary that chief executives sometimes face: when do the costs of keeping brilliant leaders who cannot seem to get along with others outweigh the benefits?

The tipping point that led to Mr. Sinofsky’s departure came after an accumulation of run-ins with Mr. Ballmer and other company leaders, rather than a single incident, according to interviews with several current and former Microsoft executives who declined to be named discussing internal matters.

One example of the kind of behavior that hurt Mr. Sinofsky’s standing at the company occurred this year at a two-day retreat for Microsoft’s senior executives at the Semiahmoo resort on the coast just below the Canadian border in Washington State. At the meeting, Microsoft’s various division heads were expected to make presentations on their businesses, answer questions and remain to hear their peers repeat the exercise.

When Mr. Sinofsky stood on the first day to speak about the Windows division, he told the group he had not prepared a presentation, and if they wanted to catch up on the progress of Windows 8, they could read his company blog, where he publicly chronicled the software’s development. He answered questions from the audience and then left the resort, while his colleagues remained until the next day, according to multiple people who were present.

Mr. Sinofsky’s early exit and halfhearted presentation were widely noted by his colleagues, irking even his admirers in the company. “He lost a lot of support,” one attendee said.

It wasn’t until this Monday, though, that Mr. Sinofsky and Mr. Ballmer both decided it would be best if Mr. Sinofsky left. Bill Gates, Microsoft’s chairman, supported the move, a person briefed on the matter said. Mr. Sinofsky served as a technical assistant to Mr. Gates in the 1990s.

In an e-mail to Microsoft employees, Mr. Sinofsky said the decision to leave “was a personal and private choice.” Many surprised Microsoft insiders noted that Mr. Sinofsky’s departure was immediate, an unusual arrangement for someone with a 23-year track record at the company. A Microsoft spokesman, Frank Shaw, said Mr. Sinofsky was not available to comment.

Although Mr. Ballmer grew increasingly impatient with Mr. Sinofsky throughout the year, he held back from taking any action earlier to avoid disrupting the release of Windows 8, the most important product Microsoft has unveiled in years, a person with knowledge of his thinking said.

The final decision could not have come lightly. Although many people at Microsoft viewed him as a ruthless corporate schemer, Mr. Sinofsky ran the highly complex organization responsible for Windows as a disciplined army that met deadlines, and he was respected by people on his team.

He achieved hero status within Microsoft several years ago by taking over the leadership of Windows after the debacle that was Windows Vista, a much-delayed operating system whose sluggish performance and technical problems worsened Microsoft’s reputation for mediocre software. Mr. Sinfosky led the development of a new version of the operating system, Windows 7, which was positively reviewed and sold well.

“He did great things with Windows,” said Michael Cusumano, a professor at the Sloan School of Management at the Massachusetts Institute of Technology. “That’s still the core of the company.”

But while Mr. Sinofsky was effective, Mr. Cusumano said, he could be secretive and difficult to get along with, as he learned while dealing with Mr. Sinofsky while Mr. Cusumano was writing a book on Microsoft in the early 1990s. “I could imagine that he burned a lot of bridges and created a bunch of enemies,” he said.

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Top U.S. Commander in Afghanistan Is Linked to Petraeus Scandal

PERTH, Australia — Gen. John Allen, the top American and NATO commander in Afghanistan, is under investigation for what a senior defense official said early Tuesday was “inappropriate communication'’ with Jill Kelley, the woman in Tampa who was seen as a rival for David H. Petraeus’s attentions by Paula Broadwell, the woman who had an extramarital affair with Mr. Petraeus.

Thierry Charlier/Agence France-Presse — Getty Images

Gen. John Allen in October.

In a statement released to reporters on his plane en route to Australia early Tuesday, Defense Secretary Leon E. Panetta said that the F.B.I. on Sunday had referred “a matter involving” General Allen to the Pentagon.

Mr. Panetta turned the matter over to the Pentagon’s inspector general to conduct an investigation into what the defense official said were 20,000 to 30,000 pages of documents, many of them e-mails between General Allen and Ms. Kelley, who is married with children and lives in Tampa, Fla.

Asked if the F.B.I. had determined that there was criminal action involved, the defense official replied, “That is for the F.B.I. to discuss.'’ The official, who briefed reporters on Mr. Panetta’s plane, said that “there is the distinct possibility'’ that the e-mails were connected to an ongoing F.B.I. investigation into Mr. Petraeus and Ms. Broadwell.

The defense official said that General Allen, who is also married, told Pentagon officials he had done nothing wrong. Neither he nor Ms. Kelley could be reached for comment early Tuesday. Mr. Panetta’s statement praised General Allen for his leadership in Afghanistan and said that “he is entitled to due process in this matter.'’

But the Pentagon inspector general’s investigation opens up what could be a widening scandal into two of the most prominent generals of their generation — Mr. Petraeus, who was the top commander in Iraq and Afghanistan before he retired from the military and became director of the C.I.A., only to resign on Friday because of the affair, and General Allen, who also served in Iraq and now commands 68,000 American troops in Afghanistan.

Although General Allen will remain the commander in Afghanistan, Mr. Panetta said that he had asked President Obama to put on hold General Allen’s nomination to be the commander of American forces in Europe and the Supreme Allied Commander of NATO, two positions he was to move into after what was expected to be easy confirmation by the Senate. Mr. Panetta said in his statement that Mr. Obama agreed with his decision.

Gen. Joseph A. Dunford, the assistant commandant of the Marine Corps who was nominated last month by Mr. Obama to succeed General Allen in Afghanistan, will proceed as planned with his confirmation hearing. In his statement, Mr. Panetta urged the Senate to act promptly on his nomination.

The defense official said that the e-mails between Ms. Kelley and General Allen spanned the years 2010 to 2012. The official could not explain why there were so many pages of e-mails and did not specify their content. The official said he could not explain how the e-mails between Ms. Kelley and General Allen were related to the e-mails between Mr. Petraeus and Ms. Broadwell and e-mails between Ms. Broadwell and Ms. Kelley.

In what is known so far, Ms. Kelley went to the F.B.I. last summer after she was disturbed by harassing e-mails. The F.B.I. began an investigation and learned that the e-mails were from Ms. Broadwell. In the course of looking into Ms. Broadwell’s e-mails, the F.B.I. discovered e-mails between Ms. Broadwell and Mr. Petraeus that indicated they were having an extramarital affair. Ms. Broadwell, officials say, saw Ms. Kelley as a rival for her affections with Mr. Petraeus.

The defense official said he did not know how General Allen and Ms. Kelley knew each other. General Allen has been in Afghanistan as the top American commander since July 2011, although before that he lived in Tampa as the deputy commander for Central Command, which oversees American military operations in the Middle East.

The defense official said that the Pentagon had received the 20,000 to 30,000 pages of documents from the F.B.I. and was currently reviewing them.

The defense official said that at 5 p.m. Washington time on Sunday Mr. Panetta was informed by the Pentagon’s general counsel that the F. B. I had the thousands pf pages of e-mails between General Allen and Ms. Kelley. Mr. Panetta was at the time on his plane en route from San Francisco to Honolulu, his first stop on a weeklong trip to the Pacific and Asia. Mr. Panetta notified the White House and then the leaders of the Senate and House Armed Services Committee.

General Allen is now in Washington for what was to be his confirmation hearing as commander in Europe. That hearing, the official said, will now be delayed.

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Lakers intrigued by chance to play for D’Antoni

EL SEGUNDO, Calif. (AP) — Pau Gasol got home from the game and read about it on Twitter, while Dwight Howard got a midnight message on his BlackBerry. They shared most Los Angeles Lakers fans’ mix of surprise, trepidation and anticipation.

Just when everybody thought the Lakers were getting back together with Phil Jackson, they switched course in the middle of the night and went with Mike D’Antoni.

What a weekend in Hollywood — and the real drama isn’t over yet.

The Lakers reacted with ample excitement and a little bewilderment Monday to their front office’s surprising decision to hire D’Antoni as coach Mike Brown’s replacement over Jackson, the 11-time champion who discussed the job at his home Saturday and apparently wanted to return. D’Antoni didn’t even interview for the job in person, speaking to the Lakers over the phone.

“It has been crazy, but all this stuff will just make this team stronger,” said Howard, who has been in a Lakers uniform for about six weeks. “Everything that we’ve been through so far, it’s going to make us stronger, and we have to look at this as a positive situation.”

The Lakers’ third coach in four days won’t take over the team until later in the week. D’Antoni still hadn’t been cleared to travel Monday after undergoing knee replacement surgery earlier in the month, although the Lakers are optimistic the former Knicks and Suns coach will arrive in Los Angeles on Wednesday.

So interim coach Bernie Bickerstaff was still in charge Monday when the Lakers gathered for an informal workout ahead of Tuesday’s game against San Antonio. Just two weeks into the regular season, the Lakers (3-4) are about to start over with a new offense and another coaching staff — and a renewed certainty they’re expected to compete for a title this season.

“It’s been a zoo,” said forward Antawn Jamison, a 15-year NBA veteran who played for D’Antoni on a U.S. national team. “But as I was telling somebody, it’s just a typical day here in L.A. It’s interesting. … It should be a lot easier to adjust to than the system we were trying to get adjusted to early on in the season. We’ve got Steve (Nash) that can help us out.”

Two Lakers who supported both Brown and his two potential replacements weren’t available in El Segundo to weigh in on the hire. Nash missed the workout while getting treatment on his injured leg, while Kobe Bryant left before it ended to share a helicopter ride back home to Orange County with point guard Steve Blake, who needed an exam on his abdominal injury.

And the tall, professorial coach with all the rings wasn’t at the Lakers’ training complex at all.

Just 24 hours after Jackson seemed headed back to his oversized chair on the Staples Center bench, D’Antoni had the job.

It’s too soon to tell how the Buss family’s latest counterintuitive move will sit with Lakers fans, who chanted “We want Phil!” during the club’s weekend games, both victories after a 1-4 start.

“I think everybody had expectations about it, and they were all pretty high,” Gasol said of Jackson’s potential return. “We all understood what Phil brings to the table … and what he means to the city and the franchise. It just couldn’t work out for whatever reason.”

Jackson issued a statement to a handful of media outlets Monday, implying he was essentially offered the job after meeting with Lakers owner Jim Buss and general manager Mitch Kupchak. Jackson thought he would be able to come back to the Lakers on Monday with his decision, but instead was awakened by a midnight phone call from Kupchak.

“The decision is of course theirs to make,” Jackson said in his statement. “I am gratified by the groundswell of support from the Laker fans who endorsed my return, and it is the principal reason why I considered the possibility.”

The Lakers largely echoed the thoughts of Howard, who was looking forward to playing for Jackson: “Management had to do what they felt is best for the team, and we as players have got to find a way to win.”

The Lakers publicly offered no reason for passing over the coach with the most championships in NBA history. Although nobody could claim the Buss family is afraid of spending money, Brown is still owed well over $ 10 million for the remaining three seasons on his four-year, $ 18 million contract, while D’Antoni will make $ 4 million a season for the next three years — and their salaries together might be less than what Jackson would command.

The Lakers largely know what they would get with Jackson, but D’Antoni intrigues this older, top-heavy team with an urgency to contend for a title before Howard’s free agency next summer and Bryant’s possible retirement in a few years.

Howard and Gasol both believe D’Antoni’s up-tempo style can work well for the Lakers. Howard would seem to be a natural to partner with Nash in the pick-and-roll attacks loved by D’Antoni and Nash, although Gasol doesn’t immediately fit into the definition of a big man who can play on the perimeter and shoot 3-pointers.

“It’s a great system, (but) I don’t think he ever had a defender such as myself or a defender such as Dwight Howard on those teams,” Metta World Peace said. “I don’t think he ever coached those type of players, so his defense should be self-explanatory, and his offense is amazing, so it should be fun for Laker fans.”

The rest of the NBA sat back and watched the Lakers’ drama with amusement over the past two days, with Dallas owner Mark Cuban weighing in gleefully on the mess: “I hope they have to do it again and again and again.”

Jackson’s flirtation with the job is the strongest indication yet that he’s interested in coaching again, which makes him a prime candidate for another franchise. Yet D’Antoni also received praise around the league — even from New York, where he resigned last March after failing to win a playoff game in four years with the Knicks.

“Despite all the hoopla … that was going on about me and Mike, we actually have a pretty good relationship, especially behind closed doors,” Carmelo Anthony said. “We actually talked a lot, talked basketball. Hopefully he brings some positive energy over there. Anytime guys are losing like that, there’s always negativity, a lot of negative energy. So sometimes change is better.”

Added Dwyane Wade, who has played for D’Antoni on the U.S. national team: “He has a tough job ahead of him, but I’m sure he’s excited about the opportunity that he gets to be with America’s team.”

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AP Sports Writers Brian Mahoney and Chris Duncan contributed to this report.

Gadgets News Headlines – Yahoo! News

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'Skyfall' brings record Bond debut of $88.4M

LOS ANGELES (AP) — James Bond is cashing in at the box office.

"Skyfall," the 23rd film featuring the British super-spy, pulled in a franchise-record $88.4 million in its U.S. debut, bringing its worldwide total to more than $500 million since it began rolling out overseas in late October.

The top 20 movies at U.S. and Canadian theaters Friday through Sunday, followed by distribution studio, gross, number of theater locations, average receipts per location, total gross and number of weeks in release, as compiled Monday by Hollywood.com are:

1. "Skyfall," Sony, $88,364,714, 3,505 locations, $25,211 average, $90,564,714, one week.

2. "Wreck-It Ralph," Disney, $33,012,796, 3,752 locations, $8,799 average, $93,647,405, two weeks.

3. "Flight," Paramount, $14,785,097, 2,047 locations, $7,223 average, $47,455,396, two weeks.

4. "Argo," Warner Bros., $6,617,229, 2,763 locations, $2,395 average, $85,583,187, five weeks.

5. "Taken 2," Fox, $4,012,829, 2,487 locations, $1,614 average, $131,300,000, six weeks.

6. "Cloud Atlas," Warner Bros., $2,658,250, 2,023 locations, $1,314 average, $22,844,956, three weeks.

7. "The Man With the Iron Fists," Universal, $2,592,705, 1,872 locations, $1,385 average, $12,821,030, two weeks.

8. "Pitch Perfect," Universal, $2,573,350, 1,391 locations, $1,850 average, $59,099,993, seven weeks.

9. "Here Comes the Boom," Sony, $2,522,790, 2,044 locations, $1,234 average, $39,033,885, five weeks.

10. "Hotel Transylvania," Sony, $2,400,226, 2,566 locations, $935 average, $140,954,208, seven weeks.

11. "Paranormal Activity 4," Paramount, $1,980,033, 2,348 locations, $843 average, $52,600,612, four weeks.

12. "Sinister," Summit, $1,524,448, 1,554 locations, $981 average, $46,578,686, five weeks.

13. "Silent Hill: Revelation," Open Road Films, $1,300,137, 1,902 locations, $684 average, $16,383,406, three weeks.

14. "The Perks of Being a Wallflower," Summit, $1,132,924, 607 locations, $1,866 average, $14,614,770, eight weeks.

15. "Lincoln," Disney, $944,308, 11 locations, $85,846 average, $944,308, one week.

16. "Alex Cross," Summit, $911,973, 1,090 locations, $837 average, $24,603,042, four weeks.

17. "Fun Size," Paramount, $757,223, 1,301 locations, $582 average, $8,800,336, three weeks.

18. "Looper," Sony, $582,150, 491 locations, $1,186 average, $64,669,383, seven weeks.

19. "The Sessions," Fox, $545,550, 128 locations, $4,262 average, $1,655,222, four weeks.

20. "Seven Psychopaths," CBS Films, $404,812, 356 locations, $1,137 average, $14,098,469, five weeks.

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Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.

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Online:

http://www.hollywood.com

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Lance Armstrong Cuts Officials Ties With His Livestrong Charity

In the wake of being stripped of his seven Tour de France titles for doping, Lance Armstrong last week cut all official ties with Livestrong, the charity he founded 15 years ago while he was treated for testicular cancer.

On Nov. 4, he resigned from the organization’s board of directors; he had previously stepped down as the chairman of the board Oct. 17. He has distanced himself from the charity to try to protect it from any damage caused by his doping controversy, the new board chairman, Jeff Garvey, said in a statement.

“Lance Armstrong was instrumental in changing the way the world views people affected by cancer,” Garvey said. “His devotion to serving survivors is unparalleled, and for 15 years, he committed himself to that cause with all his heart.”

Garvey said that the Armstrong family had donated nearly $7 million to the foundation and that the organization under Armstrong had raised close to $300 million to serve cancer survivors.

Last month, the United States Anti-Doping Agency made public its evidence in its doping case against Armstrong, saying he had doped and encouraged his teammates to dope so they could help him win races. He was subsequently barred from Olympic sports for life and was stripped of all the cycling titles he won from August 1998 on.

Since then, Armstrong has spent several weeks in Hawaii, out of the public eye. On Saturday, though, he posted a photograph on Twitter showing him at home in Austin, Tex. He is lounging on a couch with his seven yellow Tour jerseys framed on the wall in the background.

In the post, he said, “Back in Austin and just layin’ around.” The photograph had more than 400,000 page views as of Monday evening, with many people posting negative comments on the page.

“Lance, you have no moral conscious and it’s obvious many of your followers don’t either,” said one person who went by the Twitter handle “irobot,” who also posted that Armstrong needed “professional help.”

A person posting under the name “Aumann” said: “An art thief enjoying all his da Vincis.”

Other people posted words of support, including many who said they still thought Armstrong was the top cyclist in history.

“TomShelton” said of Armstrong’s seven Tour titles, “You earned all 7 of them no matter what is being said about you!”

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False Posts on Facebook Undermine Its Credibility

SAN FRANCISCO — The Facebook page for Gaston Memorial Hospital, in Gastonia, N.C., offers a chicken salad recipe to encourage healthy eating, tips on avoiding injuries at Zumba class, and pictures of staff members dressed up at Halloween. Typical stuff for a hospital in a small town.

But in October, another Facebook page for the hospital popped up. This one posted denunciations of President Obama and what it derided as “Obamacare.” It swiftly gathered hundreds of followers, and the anti-Obama screeds picked up “likes.” Officials at the hospital, scrambling to get it taken down, turned to their real Facebook page for damage control. “We apologize for any confusion,” they posted on Oct. 8, “and appreciate the support of our followers.”

The fake page came down 11 days later, as mysteriously as it had come up. The hospital says it has no clue who was behind it.

Fakery is all over the Internet. Twitter, which allows pseudonyms, is rife with fake followers, and has been used to spread false rumors, as it was during Hurricane Sandy. False reviews are a constant problem on consumer Web sites.

Gaston Memorial’s experience is an object lesson in the problem of fakery on Facebook. For the world’s largest social network, it is an especially acute problem, because it calls into question its basic premise. Facebook has sought to distinguish itself as a place for real identity on the Web. As the company tells its users: “Facebook is a community where people use their real identities.” It goes on to advise: “The name you use should be your real name as it would be listed on your credit card, student ID, etc.”

Fraudulent “likes” damage the trust of advertisers, who want clicks from real people they can sell to and whom Facebook now relies on to make money. Fakery also can ruin the credibility of search results for the social search engine that Facebook says it is building.

Facebook says it has always taken the problem seriously, and recently stepped up efforts to cull fakes from the site. “It’s pretty much one of the top priorities for the company all the time,” said Joe Sullivan, who is in charge of security at Facebook.

The fakery problem on Facebook comes in many shapes. False profiles are fairly easy to create; hundreds can pop up simultaneously, sometimes with the help of robots, and often they persuade real users into friending them in a bid to spread malware. Fake Facebook friends and likes are sold on the Web like trinkets at a bazaar, directed at those who want to enhance their image. Fake coupons for meals and gadgets can appear on Facebook newsfeeds, aimed at tricking the unwitting into revealing their personal information.

Somewhat more benignly, some college students use fake names in an effort to protect their Facebook content from the eyes of future employers.

Mr. Sullivan declined to say what portion of the company’s now one billion plus users were fake. The company quantified the problem last June, in responding to an inquiry by the Securities and Exchange Commission. At that time, the company said that of its 855 million active users, 8.7 percent, or 83 million, were duplicates, false or “undesirable,” for instance, because they spread spam.

Mr. Sullivan said that since August, the company had put in place a new automated system to purge fake “likes.” The company said it has 150 to 300 staff members to weed out fraud.

Flags are raised if a user sends out hundreds of friend requests at a time, Mr. Sullivan explained, or likes hundreds of pages simultaneously, or most obvious of all, posts a link to a site that is known to contain a virus. Those suspected of being fakes are warned. Depending on what they do on the site, accounts can be suspended.

In October, Facebook announced new partnerships with antivirus companies. Facebook users can now download free or paid antivirus coverage to guard against malware.

“It’s something we have been pretty effective at all along,” Mr. Sullivan said.

Facebook’s new aggressiveness toward fake “likes” became noticeable in September, when brand pages started seeing their fan numbers dip noticeably. An average brand page, Facebook said at the time, would lose less than 1 percent of its fans.

But the thriving market for fakery makes it hard to keep up with the problem. Gaston Memorial, for instance, first detected a fake page in its name in August; three days later, it vanished. The fake page popped up again on Oct. 4, and this time filled up quickly with the loud denunciations of the Obama administration. Dallas P. Wilborn, the hospital’s public relations manager, said her office tried to leave a voice-mail message for Facebook but was disconnected; an e-mail response from the social network ruled that the fake page did not violate its terms of service. The hospital submitted more evidence, saying that the impostor was using its company logo.

Eleven days later, the hospital said, Facebook found in its favor. But by then, the local newspaper, The Gaston Gazette, had written about the matter, and the fake page had disappeared.

Facebook declined to comment on the incident, and pointed only to its general Statement of Rights and Responsibilities.

The election season seems to have increased the fakery.

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